Effects of Cassia Sieberiena Leaf Extract Intestinal Motility of Rat

The in-vitro effects of methanolic extract (MCSL) and aqueous infusion (ACSL) o sieberiena on the motility of the rat intestines were studied and compared with tho (MCAL and ACAL) “Senna”. All the extracts and infusion relaxed the ileum dose-d effects were blocked by tolazoline, indicating that α–adrenergic receptors were contracted the colon dose-dependently and was blocked by atropine(1.7x10 M (2.8x10M). ACSL contracted this segment at 2.0-8.0 mg/ml and relaxed it at 8 relaxant effect was blocked by tolazoline (1.0x10M), indicating the involvemen receptors . MCAL had a slight relaxant effect on the colon, while ACAL c dependently and was blocked by promethazine (3.1x10M) and nifedipine (2.8 x that H1-receptor stimulation and increased intracellular calcium ion concentra MCSL was more potent than ACAL, while ACSL and ACAL were equipotent colon. With proper processing C. sieberiena can be substituted for C. acutifolia.